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2016


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Deliverables


ETOX Project line

 

 

 

 

 

 

 

Deliverables

 

. Submitted to the IMI

Del. No. Deliverable name WP No. Nature Delivery date
0.1

First Report on Data Extraction

0 R M3
8.1

Project Handbook

8 R M3
2.1

Identification and organization of relevant (textual)

2 O M4
0.2

First Reoirt ib Data Ckassification

0 R M5
1.1

Database specification

1 R M5
1.2

Predictive system requirements

1 R M6
2.2

First version of the common ontology

2 O M6
0.3

Feasibility report on data gathering and processing

0 R M9
1.3

Procedures document for maintining security of data, specially structural data

1 R M11
1.4

Functioning database management system containing the primary dataset

1 O M12
2.4

Development and validation of the semi-automated data extraction application

2 R M12
3.1

Review of available approaches to predict pure-chemistry drug toxicities

3 O M12
3.2

Report on transporters and their endogenous ligands related to drug toxicity

3 R M12
3.3

Report on the performance of ligand-based off-target pharmacology methods to predict the binding and functional profiles of compounds

3 R M12
3.4

In silico tools for prediction of metabolite structures

3 O M12
3.5

Predictive in silico affinity models for CYP off-targets

3 O M12
4.1

Progress report on QSAR modelling

4 R M12
4.2

Report on requirement and specifications for developing and validating QSAR models

4 R M12
8.2

Communication Plan

8 R M12
8.3

Technical and Financial Annual Reports #1

8 R M12
0.4

Final report on data gathering and processing (first document)

8 R M12 > M18
2.6

Development and validation of the text mining application using the EMEA EPAR dataset

2 R M18
3.6

Report describing the proposed strategy for the generation of structure/sub-structure based categories to predict drug toxicities

3 R M18
3.7

Report on ligand-based approaches to predict off-target pharmacology of drug candidates and their matabolites

3 R M18
3.8

In silico models for prediction of interaction profiles of compounds and their metabolites with transporters related to drug toxicity

3 O M18
4.3

Progress report on other mathematical and statistical analysis

4 R M18
5.1
In silico chemogenomics 5 O M18
6.1
Detailed description of the integrative software specifications and architecture 6 O M18
5.2
Interface between databases 5 O M21
2.3
Consolidated and validated version of the common ontology 2 O M12 > M24
3.9
Predictive in silico affinity models for selected off-targets 3 O M24
3.10
In silico models for prediction of compounds that can undergo phase II metabolism 3 O M24
5.3
Chemical pharmaco-toxicological network 5 O M24
8.4
Technical and Financial Annual Reports #2 8 R M24
6.2
Release of the system's prototype application 6 P M26
0.4
Final report on data gathering and processing (second document) 0 R M12 > M30
1.5
Interim report on database development, management and updates to data content 1 R M30
3.11
Report describing reactivity-based approaches to predict drug toxicity 3 R M24 > M30
3.12
In silico models for prediction of different animal in vivo ADME parameters 3 O M30
4.4
Repository for QSAR and predictive models, and tools for their development 4 O M30
5.4
Inter-species toxicological profiles 5 R M30
8.5
Interim Report on Dissemination Activities and use of Results 8 R M30
2.7
Updates and expansions of the text mining tools and the datasets 2 O M34
2.5
Updates and expansions of the ontology 2 O M18 > M36
5.5
Inter-individuals toxicological network 5 R M36
8.6
Technical and Financial Annual Reports #3 8 R M36
6.3
Release of the first version of the system 6 O M38 > M40
5.6
Tissue-protein association network 5 O M42
7.1
Report on the Verification, Evaluation, Characterisation and Validation of In silico models for Toxicity Prediction 7 R M42
8.7
Updated Dissemination and Use Plan Results 8 R M42
5.7
Biomarkers identification 5 O M45
7.2
Report on the Proposed Workflow for the Verification, Evaluation, Characterisation and Validation of in silico Models for Toxicity Prediction 7 R M45
7.3
Report on the Process of the Verification of in silico Models for Toxicity Prediction 7 R M45
7.4
Report on the Process of the Characterisation of in silico Models for Toxicity Prediction 7 R M45
3.13
Framework and protocols for predicting structure-based affinity and selectivity between CYPs and other selected off-targets 3 R M42 > M46
8.8
Technical and Financial Annual Reports #4 8 R M48
4.5
Progress report on QSAR and predictive models 4 R M50
5.8
Integrative systems chemical-biology network 5 O M50
7.5
Report on the Process of the Verification, Evaluation, Characterisation and Validation of an Initial In Silico Model for Toxicity Prediction 7 R M48 > M51
0.5
Interim report on data gathering from new sources of experimental data 0 R M52
6.4
Release of the final version of the system 6 O M52
9.1
Report on market analysis and potential business models 9 R M52
2.8
Report on text mining for toxicology 2 R M54
3.14
Report describing the relationship of ligand-transporter interaction profiles and toxicity parameters 3 R M42 > M54
8.9
Interim report on synergies with other initiatives and levarage of results 8 R M55
0.4
Final report on data gathering and processing (third document) 0 R M12 > M60
8.10
Updated Report on Dissemination Activities 8 R M60
8.11
Technical and Financial Annual Reports #5 8 R M60
5.9
User and technical requirements on systems for linkage to human safety information 5 R M50 > M64
3.15
Report on updates of molecular approaches developed 3 R M50 > M65
8.12
Interim report on eTOX potential for use by health authorities and regulatory agencies 8 R M66
2.10
Guidelines and tools for data curation 2 R M66
5.10
First report on development of systems connecting to human safety 5 R M66
9.2
Report on applicable licensing models, conditions and limitations 9 R M60 > M69
2.9
Report on liaison with standard bodies 2 R M54 > M70
0.6
Interim report on new industry legacy data gathering 0 R M72
6.5
Release of a service pack 6 O M72
8.13
Technical and Financial Annual Reports #6 8 R M72
0.7
Systems for automatic industry data extraction and submission 0 R M72
4.6
Report on usage of new data types for modelling activities 4 R M55 > M72
4.7
Repository of enhanced predictive models 4 R M72
4.8
Report on multiscale and multilevel modelling approaches 4 R M72
9.3
First version of eTOX business plan 9 R M72
7.6
Report summarising the Validation Exercises Undertaken for the In Silico Model for Toxicity Prediction in the eTOX Project 7 R M81
6.6
Release of service pack 6 O M81
0.8
Final report on data gathering, including implmentation of new strategies and plans for continuing collection after the project 0 R M84
1.6
Final Report on database development, management and updates to data content 1 R M84
2.11
Final report on ontologies and data curation 2 R M84
5.11
Final report on development of systems connecting to human safety 5 R M84
8.14
Technical and Financial Annual Reports #7 8 R M84
8.15
Final Report on knowledge management, synergy and interfacing with other projects 8 R M84
8.16
Final Report on eTOX potential for use by health authorities and regulatory agencies 8 R M84
8.17
Final Report on Dissemination Activities 8 R M84
9.4
Final version of eTOX business plan 9 R M84